- Naltrexone, used to lower cravings in opioid addicts and alcoholics. It acts by blocking opioid receptors in the brain.
- Bupropion, the same drug that's in the antidepressant Wellbutrin and the anti-smoking aid Zyban.
Outcomes: (56 Week Time Frame)
- In one trial, 48% of the patients lost more than 5% of their body weight after 56 weeks, compared with 16.4% of those taking a placebo. Average of 17.6lbs lost.
- In another trial, the numbers were 56.3% compared with 17.1% for controls. Average of 17.5lbs lost.
- The amount of weight loss, on average, was 6.1% and 6.4% in the two trials, compared with 1.3% and 1.2% of those on placebos, in that time frame.
- Alerts for similar concoctions warn that consumers may experience hostility, depression and other mood changes, and such warnings have been noted for Wellbutrin as well.
- Constipation, headaches, gall bladder infections, seizures.
- Being pushed to have a "Black Box" label, a suicidal thoughts disclaimer!
Video: ABC News "Weight Loss in a Pill"
Article: U.S. News.com - "Weight-Loss Drug Shows Promise"
Blog: L.A. Times "Contrave: New Weight-Loss Hope?"